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M9490440.TXT
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1994-09-19
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Document 0440
DOCN M9490440
TI Malignant lymphoma associated with experimentally induced feline
immunodeficiency virus infection.
DT 9411
AU Poli A; Abramo F; Baldinotti F; Pistello M; Da Prato L; Bendinelli M;
Department of Animal Pathology, University of Pisa, Italy.
SO J Comp Pathol. 1994 May;110(4):319-28. Unique Identifier : AIDSLINE
MED/94334417
AB A malignant low-grade B-cell lymphoma, primarily in the kidney, is
described in a specific-pathogen-free cat experimentally infected with
feline immunodeficiency virus (FIV) and free of feline leukaemia virus.
At the time of diagnosis the cat showed a marked reduction of
circulating CD4+ T lymphocytes, was 2 years old, and had been infected
for 18 months. FIV was isolated both from peripheral blood mononuclear
cells and the neoplastic tissue. DNA of FIV gag gene was detected in
several specimens, including the neoplastic tissue. Even if they do not
demonstrate a direct role for virus promotion of lymphomas, these and
previous observations indicate that B-cell malignant lymphoma might be
associated with FIV infection as reported for human and simian
immunodeficiency virus infections.
DE Animal Blood Cell Count Bone Marrow/PATHOLOGY Cats Feline Acquired
Immunodeficiency Syndrome/*COMPLICATIONS/
IMMUNOLOGY/MICROBIOLOGY/PATHOLOGY Female Immunodeficiency Virus,
Feline/ISOLATION & PURIF Immunoglobulins/ANALYSIS Immunohistochemistry
Kidney/PATHOLOGY Leukocyte Count Lymph Nodes/PATHOLOGY Lymphoma,
B-Cell/*COMPLICATIONS/MICROBIOLOGY/PATHOLOGY Microscopy, Electron
Specific Pathogen-Free Organisms Spleen/PATHOLOGY Support, Non-U.S.
Gov't T4 Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).